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Figure 7


Fig. 7. Description of embryonic and adult lens phenotypes produced by mixing Cx50-S50P and wild-type lens fiber connexins. This model describes the embryonic and postnatal phenotypes of various mouse lenses created by breeding heterozygous mutant (Cx50(S50P/+)–Cx46(+/+)) and double knockout (Cx50(–/–)–Cx46(–/–)) mice. The drawing explains the proposed mechanism behind development of each unique phenotype based on the electrophysiological interactions documented herein.





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