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Figure 7


Fig. 7. Overexpressing caMEK bypasses inhibition of–0.4{alpha}2(I) collagen promoter activity by the Y397F FAK mutant. Collagen promoter activity in mesangial cells was analyzed in the presence of either wild type (wt) or Y397F FAK, along with an expression vector for caMEK or its control empty vector. Luciferase values were corrected for beta-galactosidase expression and representative results (mean ± s.e.m.) obtained in triplicate from one of four separate experiments is shown. Numbers in the graph indicate fold induction by TGFbeta1. White bars, vehicle; gray or black bars, TGFbeta1 (1.0 ng/ml, 24 hours). *P<0.05 compared to each control by a post-hoc analysis.





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