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First published online November 21, 2007

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Separase loosens cohesin arm lock

Sister chromatid cohesion, which ensures faithful chromosome segregation during cell division, is mediated by cohesin. This multi-subunit complex is dismantled in two phases. The prophase pathway is thought to remove most of the cohesin from chromosome arms. Then, at anaphase, separase removes cohesin from centromeres (where the shugoshin protein Sgo1 protects it from the prophase pathway) by cleaving the cohesin subunit Scc1. Now, on p. 4188, Toru Hirota and co-workers report that the complete removal of cohesin from chromosome arms actually requires separase. Cohesion between chromosome arms is preserved if mitosis is arrested with a proteasome inhibitor (separase is activated at anaphase when its inhibitor securin is targeted for degradation by the proteasome), they report, but this cohesion is lost in Sgo1-depleted cells. They also present results that suggest that some separase activity might be present before anaphase. Overall, the authors conclude that the separase pathway dismantles a subset of cohesin complexes on the chromosome arms that, like those at the centromeres, are protected from the prophase pathway by Sgo1.

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Related articles in JCS:

The complete removal of cohesin from chromosome arms depends on separase

Masato Nakajima, Kazuki Kumada, Katsuyoshi Hatakeyama, Tetsuo Noda, Jan-Michael Peters, and Toru Hirota
JCS 2007 120: 4188-4196. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?