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Figure 1


Fig. 1. Morphology analysis of embryos obtained from Tie1-Cre-TβRIIfl/fl and Tie1-Cre-ALK5fl/fl mice. (A-C) Tie1-Cre-ALK5fl/fl littermate embryos collected at E9.5. (A) Wild type (WT); (B) Tie1-Cre-ALK5fl/fl embryo showing defects in the heart; (C) Tie1-Cre-ALK5fl/fl embryo that is approximately 1-day retarded. (D-F) Tie1-Cre-TβRIIfl/fl littermate embryos collected at E9.5. (D) Wild type; (E) Tie1-Cre-TβRIIfl/fl embryo showing defects in the heart and branchial arch; (F) Tie1-Cre-TβRIIfl/fl embryo that is approximately 1-day retarded. a, allantois; ba, branchial arch; ht, heart; ov, optic vesicle; s, somites. Scale bars, 0.5 mm.





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