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Figure 9


Fig. 9. Possible roles of LMTK2 and myosin VI in the delivery of cargo from the early endosome to the ERC. After internalisation, endocytic vesicles are delivered to and fuse with the early endosome (EE), where proteins destined for degradation are sorted and transported to the lysosome. Proteins moving back to the cell surface can either take a fast recycling route directly from the EE or a slower route via the ERC. A number of proteins including Rab11, Rab11-FIP2, EHD3, Rab4 and rabenosyn 5 have been shown to regulate trafficking between the EE and the ERC. Our results add myosin VI (an actin motor protein) and its binding partner LMTK2 (a protein kinase) to this list of proteins required for the delivery of cargo to the ERC. For the exit of receptors from the ERC the motor protein myosin Vb, and also Rab11 and EHD1 are required.





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