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Figure 1


Fig. 1. Comparison of the MDM2 and MDMX primary structures. Several functional domains are highlighted. The p53-binding domain, zinc (Zn) finger and RING finger [containing the nucleolar location signal (NoLS)] are conserved. The percentage identity shared between these domains is indicated. Although both MDM2 and MDMX contain an acidic domain, no significant conservation of amino acid sequence is found, and the acidic domain of MDMX is smaller than that of MDM2. Part of the MDMX amino acid sequence (338-407) is shown to indicate the functional domains and modification sites. Serines (S) indicated in red are validated phosphorylation sites, whereas lysines (K) indicated in blue are targets for SUMO conjugation. DVPD, caspase-3 cleavage site; NES, nuclear export signal; NLS, nuclear localization signal.





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