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Figure 4


Fig. 4. Effects of ceramide-modulating drugs on the activity of the late differentiation marker creatine kinase. L6 myoblasts were cultured for 6 days in 1% BSA medium in the absence (control) or presence of 10-7 M AVP alone, or with the addition of 20 µM fumonisin, or 100 nM myriocin, or 5 µM C6-ceramide or 10-20 µM PDMP. Creatine kinase-specific activity, expressed as the percentage of the + AVP value (1.7±0.25 OD units per minute per µg protein), was measured in cell homogenates. The mean ± s.e.m. of three measurements is shown. The absence of significant effects of FB1 or myriocin on creatine kinase activity of unstimulated cells was verified (data not shown). *Significantly different from the + AVP value, P<0.01. Three to five independent experiments gave similar results.





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