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Figure 9


Fig. 9. Model for cell shape-dependent control of Rho activity. (A) Round cells: intact filamin protein binds p190RhoGAP and prevents its accumulation in lipid rafts. p190RhoGAP is inactive and hence Rho activity is high. (B) Spread cells: filamin is cleaved by calpain, thereby releasing p190RhoGAP and allowing it to accumulate in lipid rafts where it becomes activated and suppresses Rho activity.





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