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First published online January 24, 2007

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Timely spindle control

Formation of the mitotic spindle involves a tightly regulated series of coordinated events that ultimately leads to chromosome segregation and cytokinesis. On p. 435, Stephen Huisman and colleagues investigate the role of the essential cell cycle kinase Cdc28-Clb5 in polarity of the mitotic spindle and describe a novel role for spindle pole body component Spc110 in the regulation of spindle morphogenesis in yeast. The authors performed a genetic screen to identify targets of Cdc28-Clb5 kinase involved in spindle polarity and identified a truncated version of Spc110. The truncated version, Spc110¹³, can suppress the lethal phenotype of the cdc28-4 clb5 strain. Cdc28-Clb5 localises to spindle poles and intranuclear microtubules, which is consistent with a role in spindle morphogenesis. The authors find that the Clb5-dependent kinase phosphorylates Spc110 in a cell-cycle-dependent manner at two CDK consensus sites, which is crucial for correct spindle integrity. Their data support a model whereby phosphorylation of spindle pole body components by CDK temporally controls mitotic spindle assembly and polarity at the level of astral microtubule organisation.

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Related articles in JCS:

Phosphorylation of Spc110p by Cdc28p-Clb5p kinase contributes to correct spindle morphogenesis in S. cerevisiae

Stephen M. Huisman, Monique F. M. A. Smeets, and Marisa Segal
JCS 2007 120: 435-446. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?