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First published online January 24, 2007

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The stars of pancreatic cancer

Pancreatic cancer is highly aggressive and has an extremely poor prognosis. Pancreatic cancers are characterised by a dense stromal or fibrous reaction in and around the tumour, but the effect this has on tumour progression is largely unknown. Wilhelm Schneiderhan et al. (p. 512) now demonstrate that pancreatic stellate cells (PSCs), which are responsible for the desmoplastic reaction, accelerate pancreatic tumour progression. The authors show that in pancreatic adenocarcinomas, PSCs express high levels and are the major source of matrix metalloproteinase-2 (MMP-2), which is thought to promote tumour progression. Interaction between pancreatic cancer cells and PSCs stimulates release of the extracellular matrix metalloproteinase inducer basigin, which augments MMP-2 secretion by the stellate cells. Conditioned medium from pancreatic tumour cells can stimulate expression of MMP-1 and MMP-2 in PSCs; this effect could be blocked by basigin immunodepletion. Moreover, the interaction between stellate cells and cancer cells promotes tumour growth and invasion both in vitro and in vivo. This study illustrates that the tumour-stroma interaction in pancreatic cancer promotes tumour progression and may provide a new avenue for therapeutic intervention.

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Related articles in JCS:

Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay

Wilhelm Schneiderhan, Fredy Diaz, Martin Fundel, Shaoxia Zhou, Marco Siech, Cornelia Hasel, Peter Möller, Jürgen E. Gschwend, Thomas Seufferlein, Thomas Gress, Guido Adler, and Max G. Bachem
JCS 2007 120: 512-519. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?