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First published online January 24, 2007

Journal of Cell Science 120, 305e (2007)
© The Company of Biologists Limited
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In this issue

The stars of pancreatic cancer


Figure 1

Pancreatic cancer is highly aggressive and has an extremely poor prognosis. Pancreatic cancers are characterised by a dense stromal or fibrous reaction in and around the tumour, but the effect this has on tumour progression is largely unknown. Wilhelm Schneiderhan et al. (p. 512) now demonstrate that pancreatic stellate cells (PSCs), which are responsible for the desmoplastic reaction, accelerate pancreatic tumour progression. The authors show that in pancreatic adenocarcinomas, PSCs express high levels and are the major source of matrix metalloproteinase-2 (MMP-2), which is thought to promote tumour progression. Interaction between pancreatic cancer cells and PSCs stimulates release of the extracellular matrix metalloproteinase inducer basigin, which augments MMP-2 secretion by the stellate cells. Conditioned medium from pancreatic tumour cells can stimulate expression of MMP-1 and MMP-2 in PSCs; this effect could be blocked by basigin immunodepletion. Moreover, the interaction between stellate cells and cancer cells promotes tumour growth and invasion both in vitro and in vivo. This study illustrates that the tumour-stroma interaction in pancreatic cancer promotes tumour progression and may provide a new avenue for therapeutic intervention.


Related articles in JCS:

Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay
Wilhelm Schneiderhan, Fredy Diaz, Martin Fundel, Shaoxia Zhou, Marco Siech, Cornelia Hasel, Peter Möller, Jürgen E. Gschwend, Thomas Seufferlein, Thomas Gress, Guido Adler, and Max G. Bachem
JCS 2007 120: 512-519. [Abstract] [Full Text]  




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