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Fig. 7. IQGAP3 plays important roles for axon outgrowth in hippocampal neurons. (A) The neurons were cotransfected with Myc-GST and siRNA, followed by double staining with anti-Myc (green) and Tau-1 (red) antibodies at DIV3. Arrowheads indicate the cotransfected cells that were identified by anti-Myc antibody. Axon outgrowth was impaired in the neurons transfected with either siIQGAP2 or siIQGAP3. The results shown are representative of seven independent experiments. Bar, 20 µm. (B) Quantification of the length of the longest primary axon. The axon length was measured in the cells cotransfected with Myc-GST and the indicated siRNA. Data represent the means ± s.d. of five independent experiments. n>150. Asterisks indicate a significant difference from the value of the control cells at P<0.01.
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