QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online February 7, 2007

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

A new IQGAP

The Rho family GTPases control diverse cellular processes through a large group of effector mlecules, which elicit specific physiological responses. On p. 567, Kozo Kaibuchi's group identify a novel member of the IQGAP family of Rho family effectors, IQGAP3. They demonstrate that it interacts with and functions as an effector for the activated Rho GTPases Rac1 and Cdc42. Furthermore, they show that it directly associates with actin filaments in vivo through its N-terminal calponin homology domain (CHD). IQGAP3 is highly expressed in the brain and localises to the distal tips of axons in hippocampal neurons. Using an siRNA approach the authors demonstrate that IQGAP3, unlike IQGAP1, is necessary for neurite outgrowth in PC12 cells in response to nerve growth factor (NGF) and show that this functional difference between IQGAP1 and IQGAP3 resides within the C-teminal region. Furthermore, they establish that IQGAP3 is vital for Rac1/Cdc42-directed hippocampal axon outgrowth. This study reveals that IQGAPs regulate neuronal cell morphology via their ability to organise the cytoskeleton and stabilise activated Rac1 and Cdc42 and identifies a specific role for IQGAP3 in axonal elongation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth

Shujie Wang, Takashi Watanabe, Jun Noritake, Masaki Fukata, Takeshi Yoshimura, Norimichi Itoh, Takumi Harada, Masato Nakagawa, Yoshiharu Matsuura, Nariko Arimura, and Kozo Kaibuchi
JCS 2007 120: 567-577. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?