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First published online February 7, 2007

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Cyclin different places

In yeast, the mitotic cyclin Clb2 plays a fundamental role in anaphase initiation and in the maintenance of cell shape throughout G1 phase of the cell cycle. The mechanisms by which Clb2 regulates these processes remain unclear. On p. 702, Raïssa Eluère and others demonstrate that subcellular localisation of Clb2 is a key determinant of its biological function. To investigate the relevance of Clb2 compartmentalisation the authors generated mutant versions of Clb2 that exhibit impaired nuclear import or export and analysed two Clb2-dependent processes: G2-M phase progression and the switch from apical to isotropic growth. They show that nuclear Clb2 is required for timely entry into anaphase whereas the cytoplasmic pool is required for bud morphogenesis. Furthermore, they demonstrate that degradation of Clb2 is also regulated by its localisation, the cytoplasmic form being stabilised during anaphase but not during mitotic exit. The authors propose a model whereby the switch from polarised to isotropic growth occurs when the cytoplasmic pool of Clb2 reaches an appropriate level and this is independent of cell cycle progression.

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Related articles in JCS:

Compartmentalization of the functions and regulation of the mitotic cyclin Clb2 in S. cerevisiae

Raïssa Eluère, Nicolas Offner, Isabelle Varlet, Olivia Motteux, Laurence Signon, André Picard, Eric Bailly, and Marie-Noëlle Simon
JCS 2007 120: 702-711. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?