spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 8


Fig. 8. Inhibition of ROCK impairs laminin-induced AChR clustering. To determine the contribution of ROCK to AChR clustering, the ROCK inhibitor Y27632 was added to differentiated C2 muscle cell cultures at a concentration of 20 µM. One day after treatment, the effect on laminin-induced AChR surface distribution in Y27632-treated and -untreated myotubes was quantitated and compared with the effect of ROCK inhibition on agrin-induced clustering. Inhibition of ROCK activation impaired agrin-induced AChR clustering by more than 80% (b), but only impaired laminin-induced AChR clusters by approximately 40% (d) compared with untreated cells (a,c) (error bars represent ±s.e.m.; n=100 cells from five or more separate platings).





Right arrow Return to article