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Figure 8


Fig. 8. {gamma}H2AX is associated with DSB of ENs and transcriptional silencing. (A) {gamma}H2AX domains (red) are associated with the foci (yellow) before synapsis and, when the cores synapse to form an SC (green), the {gamma}H2AX domains are minimal, which is possibly an indication that DSBs are no longer detectable. (B) At pachytene, histone H2AX of the X-Y sex chromatin is transcriptionally silenced by phosphorylation (FITC, green). As well, there are autosomal {gamma}H2AX domains (FITC, green) that do not appear to be associated with TNs (red foci) and may represent transcriptional silencing of autosomal loci. (C) {gamma}H2AX chromatin modification of the sex body and laggards (L). A further indication that pachytene chromatin modification (yellow) may be unrelated to DSBs. Typically, cores (red) that fail to synapse (laggards, L), acquire {gamma}H2AX domains in association with ATR and TOPBP1 on the unpaired cores. (D) In prematurely separated lateral elements (green) caused by okadaic acid treatment, some of the {gamma}H2AX domains (yellow) are paired (matched arrows), suggesting silencing of autosomal sites.





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