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Figure 3


Fig. 3. Increased cell surface distribution of beta-catenin in Timp3–/– MECs following Wnt3A stimulation. (A) Representative confocal images from three different experiments. The colocalization of E-cadherin and beta-catenin was examined following treatment with W0 (control ligand) and Wnt3A in WT and Timp3–/– MECs. (B) Representative confocal images of WT and Timp3–/– mouse embryo fibroblasts treated with Wnt3A or control ligand. Arrows indicate nuclear localization of beta-catenin; arrowheads indicate increased membrane colocalization of E-cadherin and beta-catenin. Bars, 20 µm.





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