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Figure 1


Fig. 1. Gain-of-function mutations in the mec-4 gene cause a degenerative state of touch receptor neurons in C. elegans. (A) Schematic representation of the position of cell bodies of the six touch receptor neurons that express pmec-4::GFP. (B) Expression of pmec-4::GFP at the L2 larval stage in a wild-type animal. Arrows show the six touch receptor neurons. (C) Expression of pmec-4::GFP at the L2 stage in a mec-4(u231) mutant. Cell death was inferred when glowing touch receptor neurons were missing from their normal positions. Arrows indicate residual pmec-4::GFP expression. (D) Nomarski image shows the morphology of a vacuolated PLM neuron (arrow) undergoing necrosis in a mec-4(u231) mutant L1 larva. Bars, 100 µm.





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