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Figure 5


Fig. 5. BEC-1 and UNC-51 interfere with neurotoxin-induced necrotic cell death. (A) Expression of pdat-1::GFP in the head dopamine neurons in a wild-type hermaphrodite. (B) pdat-1::GFP expression in a wild-type hermaphrodite exposed to the neurotoxin 6-OHDA. 6-OHDA treatment results in severe degeneration of CEP and ADE dopamine neurons, revealed by the loss of processes and/or cell bodies. (C) pdat-1::GFP expression in the head dopamine neurons of an unc-51(e1189) mutant hermaphrodite. Although in some individuals the running of the processes is slightly affected, GFP expression is similar to that found in the wild type. (D) pdat-1::GFP expression in the head dopamine neurons in an unc-51(e1189) mutant hermaphrodite exposed to 6-OHDA. (E) UNC-51 and BEC-1 deficiency suppresses 6-OHDA sensitivity of the head dopamine neurons. The percentage of animals with intact CEP and ADE neurons (both cell bodies and processes) was scored. Data are mean ± s.e.m. Empty columns represent control animals, filled columns indicate animals exposed to 6-OHDA. n=100, P<0.01 (unpaired t-test).





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