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Figure 6


Fig. 6. Influence of nutrient signaling on degenerin-induced neurotoxicity. Survival rate (%) of the six touch receptor neurons at the young adult stage in mec-4(u231) mutants with reduced CeTOR activity or exposed to starvation for 1 day at the L1 larval stage. Number of mec-4::GFP-positive cells was scored. Note that the percentage of GFP-positive cells was significantly higher in 11-day-old adults well fed during development (20.4%) than in young adults deprived of food for 1 day at the L1 stage (6.2%). Thus the effects of starvation but not starvation regimens extending development by 1 day, resulted in an increased loss of neurons. Control (OP50) animals were fed with E. coli OP50. Control RNAi (HT115) animals were fed with E. coli HT115 expressing the empty vector under RNAi-inducing conditions. let-60 encodes a component of the Ras signaling pathway. n=300, P<0.0001 (unpaired t-test). Data are mean ± s.e.m.





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