spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. BMP-9 blocks endothelial network formation. Metatarsals of 17-day-old mouse foetuses were prepared, transferred to cell culture plates and allowed to adhere for 4 days. Medium was refreshed and bones were stimulated for 7 days with BMP-9 (100 ng/ml), VEGF (50 ng/ml) or both. Cultures were fixed and vessel-like structures were visualised by anti-CD31 staining. BMP-9 inhibits baseline formation of the endothelial network. Incubation with VEGF strongly stimulated the formation of vessel-like structures, which was completely abrogated by co-stimulation with BMP-9. Six bones were stimulated per experimental group and one representative picture of each group is shown.





Right arrow Return to article