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Figure 5


Fig. 5. Interference with DRP1 rescues the SENP5-silenced phenotype. (A) COS-7 cells stably expressing vector only (panels i,ii,iii) or SENP5-specific shRNA (panels iv,v,vi) were infected with the dominant-negative DRP1-K38E-CFP-HA (infection controls are shown in insets of ii and v), or treated with dsRNA to knock-down expression of DRP1 (panels iii,vi; knock-down controls are shown in supplementary material Fig. S1) were fixed in 4% PFA for staining with monoclonal antibody against cytochrome c. Bars, 10 µm (i,ii,iv,v) and 5 µm (iii,vi). (B) Quantification of the mitochondrial phenotype observed in A. Each bar represents the mean ± s.d. of cells from three coverslips, with 50 cells examined per coverslip.





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