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Figure 8


Fig. 8. Effect of TGF-beta-induced ET-1 on endothelial cell migration. Wound healing assays: BAEC seeded on 24-well plates after confluency were wounded with a yellow pipette tip and incubated during reendothelization with medium alone (basal) or medium containing 5 ng/ml TGF-beta, TGF-beta plus 10 µM SB-431542 or TGF-beta plus 10 µM bosentan. (A) Representative images of the monolayers at 10x magnification showing initial lesions (zero time) and after 24 hours for the selected experimental conditions. (B) Estimation of cell-migration capacity was obtained by measurement of the wounded area expressed as the percentage of recovery (see Materials and Methods for details) (mean ± s.d., n=3, *P<0.05 versus basal, #P<0.05 versus TGF-beta alone).





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