QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online March 21, 2007

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Dawn arrival for condensin

During mitosis, interphase chromatin is reorganized into condensed, rigid chromosomes. This morphological change and the subsequent segregation of chromosomes requires the association of condensin I and II - protein complexes containing two ATPases of the structural maintenance of chromosomes (SMC) family and three non-SMC subunits - with the chromosomes. But what controls this? On p. 1245, Jan-Michael Peters and co-workers report that for condensin I (but not condensin II) the answer is Aurora B - a kinase that controls various stages of chromosome segregation. Using quantitative time-lapse imaging of human cells expressing GFP-labelled condensin subunits, the authors show that the loading of condensin I on to chromosomes in prometaphase and its maintenance on the chromosomes as mitosis proceeds requires Aurora B. The three non-SMC subunits of condensin I, they report, are phosphorylated by Aurora B in vitro and their phosphorylation during mitosis requires Aurora B. The authors conclude, therefore, that Aurora B contributes to chromosome rigidity and segregation during mitosis by promoting the binding of condensin I to chromatin.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes

Jesse J. Lipp, Toru Hirota, Ina Poser, and Jan-Michael Peters
JCS 2007 120: 1245-1255. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?