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Figure 5


Fig. 5. MT acetylation dampens MT dynamics. (A) Typical micrographs used to measure MT dynamics in 3x GFP-EMTB-TC-7 cells by MT end-tracking; an edge of a cell is shown with elapsed time in minutes:seconds, and four sample MT ends are shown (a-d). Bar, 10 µm. (B-C) Rates of MT (B) polymerization, (C) depolymerization, and (D) dynamicity, following 30-minute treatment with TSA or taxol, as indicated (see Materials and Methods for details). (E) The percentage of time MTs spend in a stationary phase, i.e. pausing rather than growing or shrinking, in WT, HDAC6 KO MEFs, and KO MEFs transiently transfected with HDAC6 (HDAC6 rescue MEFs). (F) Nocodazole-resistance of MT arrays in HDAC6 WT and HDAC6 KO MEFs. Error bars represent + s.e.m.; *, conditions statistically different from control (P<0.05); **, statistically significant difference both from WT control and from HDAC6 KO MEFs.





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