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Figure 7


Fig. 7. Reduced migration and scratch wound re-epithelialization of N17Rac1 transgenic keratinocytes in vitro. (a,b) Results of individual cell migration of N17Rac1 transgenic (tg) and wild type (wt) keratinocytes on collagen I (col I)-coated and fibronectin (fn)-coated dishes. Each dot shows (a) the distance covered by an individual cell (path length) or (b) the average migration speed (speed); n= 5 with three different tg and wt cell lines). Red lines indicate the mean of the respective values for each cell population. (c,d) Re-epithelialization of a scratch wound in vitro. (c) Images of scratch-wounded wt and N17Rac1 tg keratinocyte monolayers on col I 0 minutes (immediately) or 1000 minutes after scratching. (d) Graphic representation of the analysis of scratch-wound re-epithelialization in tg or wt keratinocytes on col-I- or fn-coated dishes. Graphs show the distance between the epithelial fronts (y-axis) at three different time points after scratching (x-axis) in percent. Data points represent the mean of 20 measurements each ± s.d. of the distance in four different N17Rac1 tg and 4 wt keratinocyte lines (n=6). *P<0.05; **P<0,01; *** P<0,001; ns, not significant.





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