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Figure 1


Fig. 1. Alignment of the protein sequences of IRSp53 and IRTKS. (A) Human IRSp53 (splice variant S, accession no. BAC57948) aligned with human IRTKS (NP_061330). Identical residues are highlighted in black. The region boxed with a solid line is the IMD, that with a dash-dot line is the partial CRIB motif of IRSp53, that with a dashed line is the SH3 domain and that with a dotted line is the putative WW domain interacting motif. (B) Alignment of C-terminal region of IRTKS with the variable C-terminal regions of four splice variants of IRSp53; IRSp53-L (BAC57945), IRSp53-M (BAC57946), IRSp53-T (BAC57947) and IRSp53-S (BAC57948). Splice variant names are as defined by Miyahara et al. (Miyahara et al., 2003). Dashed box indicates region present in all splice variants of IRSp53.





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