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Figure 3


Fig. 3. PDE4D4 interacts with spectrin in pulmonary endothelial cells. (A) Non-erythroid spectrin is comprised of {alpha}II and βII subunits, which form a heterotetramer. PDE4D4 dimers bind {alpha}II subunit SH3 domains. (B) Co-immunoprecipitation studies using {alpha}II spectrin antibody followed by immunoblotting with antibody to PDE4D reveal a 115 kDa band in PMVECs consistent with the PDE4D splice variant PDE4D4. Overexpression of PDE4D4 in PAECs resolved a 115 kDa band that co-immunoprecipitated with {alpha}II spectrin.





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