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Figure 1


Fig. 1. Expression of transgenic {alpha}-dystrobrevin in skeletal muscle. (A) The murine creatine kinase (MCK) promoter was used to drive expression of {alpha}-dystrobrevin-2a linked to either HA at the C-terminus or to HA followed by the Ras palmitoylation site (RPS), to force membrane association. (B) Immunoblotting of muscle homogenates using an anti-dystrobrevin antibody show the relative transgene expression of the three founder lines of TgDB (63, 68, 80), five lines of TgDB-RPS (10, 17, 27, 29, 71) and wild type (wt). The bottom part of the same immunoblot was labeled with an antibody against glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to demonstrate that similar amounts of protein were loaded on the gel.





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