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Figure 4


Fig. 4. Transgenic {alpha}-dystrobrevin expression in the mdx mouse. (A) H&E stained tibialis anterior (TA) muscle shows that the dystrophic phenotype persists in the mdx mice, despite the expression of either transgenic {alpha}-dystrobrevin. (B) The number of centrally nucleated fibers in TA (dark shade), soleus (medium shade) and diaphragm (light shade) muscles are not significantly reduced by expression of either {alpha}-dystrobrevin transgene. (C) Serum creatine kinase levels in mdx mice with or without transgenic {alpha}-dystrobrevin are also similar. Error bars give ± s.d. Data was obtained from TgDB-RPS lines 29 and 71. Scale bar, 50 µm.





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