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Figure 6


Fig. 6. Select restoration of dystrophin associated proteins by sarcolemmal {alpha}-dystrobrevin. (A,B) Palmitoylated {alpha}-dystrobrevin expressed on the sarcolemma of TA muscle of mdx mice restored the levels of {alpha}-syntrophin and AQP4 but failed to restore sarcolemmal nNOS as determined by (A) immunofluorescence and (B) immunoblots of membrane proteins. Sarcolemmal utrophin expression was not altered by sarcolemmal {alpha}-dystrobrevin. Data was obtained from TgDB-RPS lines 29 and 71. Scale bar, 50 µm.





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