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Figure 4


Fig. 4. The effect of centrin depletion is subfamily specific. For all centrins (except ICL8p), RNAi induces a complete disassembly of the ICL observed after a few cell divisions. Although the same terminal phenotype (absence of ICL, small remnants of centrin-containing material near basal bodies) is reached in most cases, the pattern of disassembly, consistently observable throughout the first divisions under RNAi conditions, depends on the targeted subfamily. (A-C) Three of the four recorded modes of disassembly. (A) ICL7p-silenced cells are shown after 24 hours (left) and 48 hours of growth (right): disassembly proceeds progressively and homogeneously. (B) In ICL10ap-silenced cells, thinning of the filament bundles precedes disassembly. (C) In ICL3d-silenced cells, aggregates of ICL material accompany disassembly. The lower panels show enlargements of the above cells. Scale bar: 15 µm.





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