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First published online December 20, 2007

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ERES keep their distance

Proteins destined for secretion are usually first transported from the ER to the Golgi complex, where they are post-translationally modified. Transport is mediated by COPII-coated vesicles, which form when COPII proteins bind at endoplasmic reticulum exit sites (ERES) and self-assemble into clusters. The size of individual ERES varies widely between closely related organisms, but the factors that govern cluster size and ERES location are not known. On page 55, Matthias Weiss and colleagues model ERES formation using a set of basic assumptions about COPII attachment, diffusion and turnover. The authors show that simulated ERES-like clusters tend to `keep their distance' from one another, forming a quasi-crystalline array of relatively evenly spaced clusters that is similar to the pattern seen in cells. Moreover, the broad size distribution of clusters predicted by the model also echoes the spread of ERES size in vivo. On the basis of their model, the authors predict that ERES size depends on the rate of COPII-protein turnover. Differences in turnover rate could therefore explain the observed interspecies differences in ERES size.

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A model for the self-organization of exit sites in the endoplasmic reticulum

Stephan Heinzer, Stefan Wörz, Claudia Kalla, Karl Rohr, and Matthias Weiss
JCS 2008 121: 55-64. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?