QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

Help viewing high resolution images Return to article

Fig. 4. Amyelination in Lama2 mutants. Resin sections of the fifth lumbar ventral root taken at P59 were stained with Toluidine Blue to assess myelination (dark rings) of motor axons. (A) All motor axons are separated and uniformly myelinated in normal mice. (B) In nmf417 homozygotes, myelinated axons are largely replaced by bundles of unmyelinated axons. Immature Schwann cells associated with bundle surfaces. Defects in myelination in nmf417/nmf417 were similar in form and degree to that observed in homozygotes for the dy^2J allele (C) and the dy allele (D). (E) In nmf417, premyelinating Schwann cells (SC) were only loosely associated with axons (arrowheads) and were not invasive. (F) In dy^2J, premyelinating Schwann cells associated more tightly with axon bundles than in nmf417. (G) Premyelinating Schwann cells in dy mutants had tight axon associations, similar to dy^2J. Invasive processes were sometimes observed to engulf an axon in dy (asterisk) and dy^2J mutants without proceeding to myelination. All images show spinal ventral roots. Scale bars: 72 µm (A-D); 2 µm (E-G).

Return to article