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Fig. 3. HK1.fos/ ${Delta}$ 5Pten synergism increases mitotic index in papillomatogenesis until KA is achieved. (A) Tabulated mitotic index from HK1.fos/ ${Delta}$ 5Pten epidermis and tumours. Despite a normal histotype, HK1.fos epidermis possessed a twofold increase in mitotic index over normal epidermis, similar to that of hyperkeratotic (HK) K14.cre/ ${Delta}$ 5Pten^flx epidermis. This index further doubled in HK1.fos/ ${Delta}$ 5Pten hyperplastic/hyperkeratotic (HPK) epidermis to levels observed in overt HK1.fos papillomas. The lower average mitotic labelling in HK1.fos/ ${Delta}$ 5Pten KAs comprised a low mitotic index in differentiated versus a very high index in papillomatous histotypes. (B) Double-labelled BrdU immunofluorescence analysis of mitotic activity. Differentiated HK1.fos/ ${Delta}$ 5Pten^flx KA histotypes show low BrdU labelling (yellow) similar to that found in HK1.fos papillomas; conversely, papillomatous areas exhibit very high BrdU labelling.

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