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Figure 5


Fig. 5. PLC activity is required for the formation of peripheral protrusions in epithelial cysts. Caco-2 cysts were treated for 12 hours with either blebbistatin alone or in combination with the PLC inhibitors ET-18-OCH3 (10 µM) or U-73122 (1 µM). Both pharmacological inhibitors of PLC significantly attenuated the formation of blebbistatin-induced spikes (*P<0.001).





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