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Figure 9


Fig. 9. Microtubules are involved in the formation of blebbistatin-induced protrusions. (A) Preformed Caco-2 cysts were treated for 12 hours with either blebbistatin alone or in combination with the microtubule-depolymerizing drugs nocodazole (30 µM) or vinblastin (10 µM). Microtubule depolymerization prevented the formation of blebbistatin-induced protrusions (*P<0.01). (B) Caco-2 cysts were treated for 12 hours with blebbistatin, fixed, and double-labeled for F-actin (green) and the microtubule marker {alpha}-tubulin (red). Microtubules are enriched in the base of blebbistatin-induced spikes (arrows).





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