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Figure 6


Fig. 6. Downregulation of myomesin by siRNA interference disrupts M-band structure and leads to loss of obscurin striations in NRCs. NRCs transfected with myomesin siRNA, visualized by GFP fluorescence, show dramatically reduced myomesin levels with loss of M-band striations. Obscurin is diffusely localized in cells treated with siRNA, except for in areas of residual myofibrils, in which it colocalizes with myomesin (arrowheads in insets). Control cells transfected with unspecific siRNA vector show no change in the localization of obscurin or sarcomeric markers ({alpha}-actinin). (Inset) Twofold-magnified area of the same image showing residual primitive stripes. Scale bars: 10 µm.





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