spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 8


Fig. 8. Model of the M-band incorporating the spatial constraints on the localization of titin, myomesin and obscurin on the basis of the protein interactions identified here and previously. The M-band lines are marked at the top of the figure. The path of titin is unknown outside the M-band, hence no precise arrangement is shown from the domains immediately N-terminal to the kinase domain. Ig and Fn3 domains are shown as ovals, the titin kinase domain (TK) as a circle and the interdomain-sequence insertions as lines. Titin M-band domains are numbered. Protein interactions are: (1) myomesin My1 and myosin; (2) obscurin/Obsl1 Ig1 with titin M10; (3) myomesin homodimerization via My13; and (4) obscurin/Obsl1 Ig3 with myomesin My4-My5. Note that this model makes no assumptions on whether titin crosses over between myosin filaments or is arranged in a strictly parallel fashion, but mechanical considerations make a crosslinking titin arrangement more plausible.





Right arrow Return to article