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Figure 6


Fig. 6. Nesprin-2-Giant KO mice are partial loss-of-function mutants. (A,B) pAbK1 immunoblot analysis of various WT and KO tissue homogenates (equal amounts loaded). Certain pAbK1-reactive Nesprin-2 C-terminal isoforms are present (arrows) and their levels are perturbed in specific KO tissues. Nesprin-2 Giant is absent in KO lysates. K56-386 detects Nesprin-2 Giant only in the WT (A). Emerin staining shows minor changes. (C,D) pAbK1 detected sarcomeric structures (arrows) and the NE (arrowheads) in WT (C) and KO (D) adult-mouse skeletal muscle frozen sections. DAPI, nuclei.





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