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Figure 1


Fig. 1. The metabolic cycle of PtdIns(4)P in yeast and mammals. The metabolic cycle of PtdIns(4)P in yeast and mammals. PtdIns(4)P can be produced through phosphorylation of PtdIns by PI4Ks and through dephosphorylation of PtdIns(4,5)P2 by PtdIns(4,5)P2-5-phosphatases (5-phosphatases). These comprise Sjl1p, Sjl2p and Sjl3p in yeast, and several members in mammals, including synaptojanin 1 and synaptojanin 2, OCRL, INPP5B, INPP5E, INPP5F, PAB5PA and SKIP. Enzymes are indicated by ellipses and the regulatory factors are connected to the PI4Ks either by continuous lines (physical interactions) or by dashed lines (functional interactions). See text for details.





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