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Figure 5


Fig. 5. The initial pre-alignment mechanism is critical for cell survival when the spindle length is compromised. (A) Wild-type cells expressing sid2-GFP and rlc1-GFP as SPB and actomyosin ring marker, respectively, were treated with 25 µg/ml of the microtubule-depolymerizing drug Carbendazim (MBC) to inhibit the fully extension of the mitotic spindle. The upper panel shows a cell that initiates SPB separation at mitosis aligned with the cellular long axis. The lower panel shows a cell that initiated SPB separation misaligned with the cellular axis. Arrowhead indicates SPBs positions over time whereas the arrows indicate the position of the contractile actomyosin ring at the division site. (B) Quantification of the result shown in A. Graph showing the correlation between initial angle of SPB separation and the frequency of finding the two poles at one side of the division plane.





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