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Figure 6


Fig. 6. Model of spindle alignment in S. pombe. (1) Interphase MTs attached to the duplicated SPB align the axis of the duplicated SPBs with the axis of the cell. The drawing at the bottom left shows duplicated SPBs containing a long and a short axis. The distances shown are approximate. (2) Microtubule dynamics is important to align the interphase MTs with the cellular axis. When MTs are too short they are often misaligned with the cellular axis and consequently the mitotic spindle will be misaligned. (3) The attachment between the mitotic spindle and the interphase MTs is critical to transmit the spatial information obtained by dynamic MTs to the duplicated SPBs at the nuclear envelope.





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