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Figure 4


Fig. 4. Localisation of Sdt proteins encoded by transgenes in sdtK85-mutant adult photoreceptor cells. Optical cross-sections of adult Drosophila eyes stained with antibodies against Sdt-PDZ (A,B,E) or with aSdt-N (C,D) (red), and phalloidin to highlight the F-actin-rich rhabdomeres (blue). (A) Sdt localises at the stalk membrane in wild-type PRCs. (B) sdtK85 eyes show morphological defects in the rhabdomeres and no Sdt protein can be detected. (C) Sdt-B2 localises at the stalk membrane when expressed in sdtK85-mutant PRCs. (D) Sdt-{Delta}PDZ localises at the rhabdomere base when expressed in sdtK85-mutant PRCs. (E) Sdt-{Delta}N is distributed throughout the cell when expressed in sdtK85-mutant PRCs. Note that the stalk of R7 is not labelled by anti-Sdt antibody in C-E, because Rh1-Gal4 is only expressed in the six outer PRCs. This makes it sometimes more difficult to detect the rhabdomere of R7.





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