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Figure 10


Fig. 10. Models of molecular organization from IF to costameres including DGC and integrin complexes. (A) The N-terminal part of plectin 1 is associated with costameres by binding β-synemin, costameric actin and {alpha}-dystrobrevin, whereas its C-terminal part is linking to IFs. Exon 1 part of plectin 1 might interact with not only {alpha}-dystrobrevin but also β-synemin, whereas β-synemin on plectin molecules might be further associated with costameric actin linking to plectin, dystrophin and metavinculin. (B) As an alternative model, direct interactions of plectin with dystrophin and β-dystroglycan were proposed by Rezniczek et al. (Rezniczek et al., 2007). This model is partly modified to represent the interaction of plectin 1 with {alpha}-dystrobrevin through its exon 1 part.





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