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Fig. 2. Genomic organisation of caveolin genes and a model for the diversification of the caveolin sequences in metazoans. (A) Genomic localisation of caveolin-encoding genes in four species. Related families are indicated by related colours: Cav1 and Cav3 are pink, Cav2 and Cav2R are green and olive, respectively, and CavY-related sequences are yellow. When two genes are in a contiguous genomic segment the transcription orientation is indicated by an arrow above each gene. The symbol `//' between Cav2R and Cav3 in Tetraodon nigroviridis indicates a long genomic segment of 
1.3 Mb. (B) This model is based on the results of the phylogenetic analysis presented in Fig. 1 and summarises the interpretation in the text. For the parts of the model for which there is no clear phylogenetic support (represented by dotted lines), the simplest evolutionary model was selected based on the caveolin gene content information in the species studied and the ability of these sequences to form caveolae structures. For the CavY group, two levels of phylogenetic support are indicated: `minimum' (supported by all the phylogenetic analysis methods used) and `extended' (supported by two to three of the four methods used).
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