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Figure 6


Fig. 6. Analysis of caveola formation using deletion mutants and hybrid proteins. (A) Topology model of caveolin. Orange boxes mark the region of interest that are shown in alignments below. (B) Sequence alignment. Dark grey, identical residues; light grey, similar residues; purple, partly conserved hydrophobic residues; red asterisks, residues mutated in breast cancer; shaded yellow region, residues that can be deleted without affecting caveola formation; red line and red text, residues that are not conserved in CeCav-a compared with all other sequences in the alignment; black asterisks, residues implicated in muscular dystrophy when mutated in HsCav3. (C) Caveolin mutants used in this study. Grey, N- and C-terminal regions; dark blue, oligomerisation domain; light blue, scaffolding domain; red, intramembrane domain. Curved lines indicate missing sections. Regions highlighted in green are from CeCav-a. Orange, regions of interest that are shown in alignments. + and – presence and absence, respectively, of caveolae according to the results of the EM caveola biogenesis assay. Scale bars indicate the number of amino acids.





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