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First published online June 4, 2008

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Crumbs and Stardust: it's complex

The Drosophila transmembrane protein Crumbs and its binding partner Stardust are members of a multiprotein complex that controls the morphogenesis of photoreceptor cells (PRCs). In adult PRCs, the Crumbs-Stardust complex localises to the stalk, a specialised apical membrane domain. Stardust contains numerous protein-protein-binding domains and is thought to act as a scaffold for other members of the Crumbs-Stardust complex – but what determines the localisation of Stardust and Crumbs? On page 2018, Elisabeth Knust and colleagues show that the domains of Stardust that are important for its localisation differ according to developmental stage. The authors show that, in the pupa (prior to the formation of the stalk), only the PDZ domain of Stardust is necessary for its apical localisation; by contrast, in the adult fly, multiple Stardust domains are required to target it to the stalk membrane. Notably, in pupal PRCs, Crumbs localises to the apical domain even when mutant Stardust does not but, in adult cells, Crumbs is unstable in the absence of stalk-associated Stardust. The authors also present data on the domains of Stardust that recruit other proteins of the Crumbs-Stardust complex. Their work highlights the intricate regulatory processes that govern PRC morphogenesis.

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Related articles in JCS:

Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila

Natalia A. Bulgakova, Özlem Kempkens, and Elisabeth Knust
JCS 2008 121: 2018-2026. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?