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Figure 8


Fig. 8. Model for trafficking of the LOX-1-OxLDL complex. The findings indicate that LOX-1 constitutively cycles between the plasma membrane (PM) and endosomes (E) in the absence of ligand. LOX-1 and LOX-1-OxLDL complexes are internalised via a dynamin-2 and clathrin-independent mechanism, which may involve the recruitment of cytosolic factors. The majority of LOX-1 dissociates from OxLDL early in the endocytic pathway and may recycle to the plasma membrane, whereas the OxLDL traffics to later endocytic compartments (L). It is likely that some LOX-1 does not dissociate from OxLDL and traffics to later endocytic compartments with subsequent degradation in a late endocytic or lysosomal compartment. Thus, LOX-1 is able to mediate the continuous uptake of OxLDL into the cell.





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