QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online June 18, 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Actin makes a move with annexin A2

The dynamic remodelling of the actin cytoskeleton is crucial for cell adhesion and motility, and can be triggered by stimuli that activate the insulin receptor (IR) and other receptor tyrosine kinases. IR activation promotes cell motility by disrupting cell-substrate contacts, but many of the steps in this signalling cascade are unknown. On page 2177, Volker Gerke and colleagues now identify a key stage in the pathway – the tyrosine phosphorylation of the phospholipid- and actin-binding protein annexin A2. The authors use baby hamster kidney cells that overexpress the human insulin receptor to show that annexin A2 is tyrosine phosphorylated in response to insulin; in addition, annexin A2 and the IR co-immunoprecipitate, which suggests that the IR phosphorylates annexin A2 directly. Rho/ROCK signalling, the authors show, mediates insulin-induced morphological changes, and knocking down annexin A2 inhibits insulin-triggered Rho activation and actin rearrangements. Importantly, a phosphotyrosine-mimicking annexin A2 mutant induces actin rearrangements in the absence of insulin. The authors propose, therefore, that the tyrosine phosphorylation of annexin A2 links IR activation to Rho/ROCK-mediated actin rearrangement and cell adhesion.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion

Ursula Rescher, Carsten Ludwig, Vera Konietzko, Alexei Kharitonenkov, and Volker Gerke
JCS 2008 121: 2177-2185. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?