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Fig. 3. Differences in inside-out activation of integrins in B and T cells. The current understanding of the early molecular events that underlie the inside-out activation of integrins in B and T cells following immunoreceptor stimulation is shown. Differences in the composition of the signalosomes that are assembled are illustrated, in terms of their differential use of proximal signalling and adaptor molecules. Molecules that have been demonstrated to be localised within the microsignalosome by high-resolution imaging are shown (blue), as well as those that have been implicated to be important by biochemical analysis (green). The Src-family kinases (Lyn and Lck) are not strictly considered to be part of the microsignalosome because they are localised to the membrane prior to antigenic stimulation; however, they are crucial for microsignalosome formation.
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